The current global pandemic, known as COVID-19, poses challenges to healthcare systems worldwide. At the same time, it has provoked a collective focus on new and disruptive technology and stimulated the application of such technologies to disease control and containment efforts. Some of the innovations that have played the most significant roles have come from the fields of artificial intelligence, big data analytics, and communications technology. The current situation provides a good opportunity to relook how medical people engage with technological advances. This narrative review attempts to provide a historical context to the adoption of technology and of technical developments in Singapore and discusses the impact of disruptive technology in healthcare.