Depression is a common disorder in the general population and is frequently encountered in the primary care setting. Recognition and appropriate diagnosis are imperative for prompt treatment to take place and will result in better outcomes for patients suffering from the disorder. Diagnosis of major depression is made when depressed mood becomes more pronounced and is accompanied by other symptoms. It is based on the DSM IV-TR criteria for major depression. It is also important to keep in mind that the diagnosis is often obscured as patients, especially the elderly, tend to present with only complaints of physical symptoms. However, a careful history and an emphatic approach from physicians will help reveal the diagnosis. A suicide assessment should be performed for all depressed patients and referral to a psychiatric service should be made if depression is severe and the risk of suicide is high.