This article explores the role of the family physician in helping couples cope with sexual difficulties in the context of their infertility experience and treatment. Sexual dysfunction can be pre-existing or as a result of infertility investigations and treatment. The initial workup in general practice consists of taking a good history and performing a physical examination. This can help exclude medical conditions that may cause sexual dysfunction. The PLISSIT (Permission, Limited Information, Specific Suggestions, Intensive Therapy) method can be used to facilitate discussions about sexual concerns.