Obesity is a complex and chronic condition that requires continuing care. A variety of diet plans are available for use in the clinical setting. Exactly what type of diet may be most beneficial remains controversial. Numerous clinical trials have been carried out over the years comparing an array of dietary interventions for weight loss, including calorie restriction diets, altered macronutrient composition diets or specific dietary patterns. This paper will provide an overview of the evidence-based dietary interventions for clinical practice.