Obesity is a complex and chronic condition that requires continuing care. A variety of diet plans are available for use in the clinical setting. Exactly what type of diet is the most beneficial remains up for debate. Numerous clinical trials have been carried out over the years comparing an array of dietary interventions for weight loss, including calorie-restricted diets, altered macronutrient composition diets, or specific dietary patterns. This paper will provide an overview of some of the evidence-based dietary interventions for clinical practice.