Dengue Fever / Dengue Haemorrhagic Fever (DF/DHF) is the commonest vector-borne viral illness globally, with frequent and cyclical epidemics. After a 15-year period of low incidence, dengue has re-emerged in Singapore in the past decade. A combination of factors, namely lowered herd immunity, significant virus transmission outside of the home, and increase in the age of infection all contribute to an increased dengue incidence. Furthermore, adult dengue cases present a unique challenge to Singapore and investment in research on disease pathogenesis and case management will be needed to overcome the disease burden of this emerging trend.