Chronic obstructive pulmonary disease or COPD, a chronic inflammatory airway disease, is one of the top 10 causes of mortality and reason for hospitalisation in Singapore. Apart from asthma, COPD is the second most common chronic respiratory disease being managed in primary care and is set to increase in prevalence due to the aging population in the local community. The Ministry of Health of Singapore has published clinical practice guidelines in 2006 to support respiratory and family physicians in providing optimal care for this group of patients based on clinical evidences. With growing amount of data and literature from research carried out globally, we examined the issues and use of evidence-based practice in managing three COPD patients with varying needs, in a local primary care centre.